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This discovery supports the hypothesis that FGF-21 has a physiological role in thermogenesis and the thermogenic recruitment of white adipose tissue browning through an autocrine-paracrine axis highlighting the plasticity of the adipose organ and the interplay between the WAT and BAT

Another study found that upregulated autophagy in aged adipocytes was due to an aging-induced decline in Rubicon, a negative regulator of autophagy [83]

Hales CM, Carroll MD, Fryar CD, Ogden CL (2020) Prevalence of obesity and severe obesity among adults: United States, 20172018

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